The Influence of Securigera securidaca on Diabetes Management in Animal Models: A Systematic Review

Background and Objective: It has been reported that allopathic drugs do not have significant effects on diabetes treatment. In contemporary literature, much attention has been given to the potential use of traditional medicines, including medicinal plants, in the treatment of metabolic abnormalities. Indeed, the effect of Securigera securidaca, as a medicinal agent, in alleviating the complications of diabetes has received marked attention, particularly in animal models. The aim of this review is to clarify the S.securidaca therapeutic effects in diabetes mellitus treatment based on animal research. Materials and Methods: PubMed, Google Scholar, and the Web of Science were searched, from inception to January 2020 to investigate the effects of S.securidaca on diabetes in animal models. Each article was critically rewired for its methodological quality using the CAMARADE tool. Results: Thirteen articles were reviewed and some positive effects of S.securidaca were observed in alloxan and Streptozotocin-induced diabetic animals. With a closer look at the mechanisms, S.securidaca is comparable with current antidiabetic drugs. The results of animal trials indicated hypoglycemic effects of S.securidaca in animal models. Conclusion: Remedies like S.securidaca could count as a treatment option for diabetic patients, alongside current antidiabetic medications, yet with fewer side-effects.